منابع مشابه
Neuroprotective therapies for glaucoma
Glaucoma is the second leading cause for blindness worldwide. It is mainly caused by glaucomatous optic neuropathy (GON) characterized by retinal ganglion cell loss, which leads to visual field defect and blindness. Up to now, the main purpose of antiglaucomatous therapies has been to lower intraocular pressure (IOP) through surgeries and medications. However, it has been found that progressive...
متن کاملNeuroprotective therapies in glaucoma: II. Genetic nanotechnology tools
Neurotrophic factor genome engineering could have many potential applications not only in the deeper understanding of neurodegenerative disorders but also in improved therapeutics. The fields of nanomedicine, regenerative medicine, and gene/cell-based therapy have been revolutionized by the development of safer and efficient non-viral technologies for gene delivery and genome editing with moder...
متن کاملNeuroprotective Agents in Glaucoma
1.1 Glaucoma as a neurodegenerative disorder Glaucoma is a multifactorial disease in which multiple genetic, systemic and environmental factors interact to precipitate the disease. Increased intraocular pressure (IOP) is believed to be one of the major factors responsible for glaucomatous cell death. (Guo et al., 2005). The axons of the optic nerve make a twisting exit through the fenestrated c...
متن کاملBad news for neuroprotective therapies in PD?
While the etiopathogenesis of Parkinson’s disease (PD) continues to fuel intense debate [1], there is little doubt that the motor features of PD are caused by the degeneration of nigrostriatal dopamine (DA) neurons [2]. Clinical symptoms have been estimated to appear when at least 50% nigral DA neurons and 70% putaminal DA tissue contents are lost [3, 4]. Dopaminergic imaging suggests that at l...
متن کاملSynergistic neuroprotective therapies with hypothermia.
Neuroprotection is a major health care priority, given the enormous burden of human suffering and financial cost caused by perinatal brain damage. With the advent of hypothermia as therapy for term hypoxic-ischemic encephalopathy, there is hope for repair and protection of the brain after a profound neonatal insult. However, it is clear from the published clinical trials and animal studies that...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drug Design, Development and Therapy
سال: 2015
ISSN: 1177-8881
DOI: 10.2147/dddt.s80594